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KMID : 0384119910110010171
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Korean Journal of Clinical Pathology
1991 Volume.11 No. 1 p.171 ~ p.182
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Determination of Human T & B Cells and Th/Ts Cells tests in Various Disorderse
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E. S. Kim
T. Y. Kim/T. Y. Choi/W. S. Chung
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Abstract
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Two major lymphocytic cell types, T and B cells, have served as a convenient focal points for examination of the immune system. B cells destined to make humoral an- tibodies can interact and somehow be amplified in their response by so called `helper T cells (Th). Evidence has been presented for the existence of a second population of T cells called `suppressor T cells (Ts), many of which function as regulators or governors for the immune response. The T/B, Th and Ts cell tests, can be evaluated for a multitude of individual immunities, and are generalized by using highly specific monoclonal antibodies that define cell surface antigens. But clinicians don`t make good use of these tests in diagnoses. The Author performed T/B, Th and Ts cell tests by double fluorochrome IF method at Hanyang University Hospital, the first such tests in Korea. The purpose of this study is to correct haphazard requests and to exhibit right clinical applications for the T/B, Th and Ts cell tests. 310 patients yielded the 580 samples(periphera1 blood &/or bone marrow) in this study, which was conducted 1987-1990. The results are as the follows : 1. T/B, Th and Ts cell tests must be requested in leukemic groups, because these results are changed according to immunity of cells in pretherapeutic and complete remission groups. Note that it is not necessary to perform tests simultaneously in peripheral blood and bone marrow. 2. The Th/Ts test ratio of peripheral blood is not increased in non-metastatic cancers. The Th/Ts test ratio of peripheral blood in metastatic cancers is decreased. So the Th/Ts ratio of peripheral blood is variable according to type of lesions and degree of metastasis. 3. In Grave`s disease and rheumatoid arthritis, the Th/Ts ratio of peripheral blood is increased, but the ratio is decreased in SLE cases with renal involvement. 4. In a chronic renal failure group with kidney transplantation, the T cell per centage of peripheral blood is decreased. 5. The reports of T/B, Th and Ts cell tests must be expressed in terms of both percentages and absolute numbers. In some cases, the percentages of T/B, Th and Ts cell test might show as normal, but as abnormal in some disorders if expressed in absolute numbers. 6. It is not necessary that T/B, Th and Ts cell of bone marrow be requested in disorders other than leukemia. 7. Clinical requests for T/B, Th and Ts cell tests are numerous. In order to define the limits of their application in clinics, we must further study the T/B, Th and Ts cell tests of peripheral blood in many diseases.
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